Safranal

Safranal, Safran (Crocus sativus) çiçeklerinden elde edilen safranda bulunan bir organik bileşiktir. Safranın aromasından başlıca sorumlu olan bileşenidir.

Safranal

Kimyasal Adı	2,6,6-trimethyl-1,3- cyclohexadiene-1-carboxaldehyde
Kimyasal formül	C₁₀H₁₄O
Molekül ağırlığı	150.21 g/mol
CAS numarası	116-26-7
Yoğunluk	0.9734 g/cm³
SMILES	CC1(C)C(C=O)=C(C)C=CC1
Kaynakça ve sorumluluk reddi

Zeaksantin isimli karotenoidin yıkımı sonucunda, pikrokrosin yoluyla meydana geldiği düşünülmektedir.

Farmakoloji

Safranal, etkili bir antikonvülsandır, GABA_A reseptörlerine agonist olarak etki eder.[1][2] Safranal ayrıca antioksidan ve serbest radikal toplayıcı etkisine sahiptir[3][4] ve in vitro kanser hücrelerine sitotoksik etkisi vardır[5].

Kaynakça

Hosseinzadeh H, Talebzadeh F. (2005). "Anticonvulsant evaluation of safranal and crocin from Crocus sativus in mice". Fitoterapia. 76 (7–8). ss. 722-4. PMID 16253437.
Hosseinzadeh H, Sadeghnia HR. (2006). "Protective effect of safranal on pentylenetetrazol-induced seizures in the rat: Involvement of GABAergic and opioids systems". Phytomedicine. ? (?). ss. ?. PMID 16707256.
Hosseinzadeh H, Sadeghnia HR. (2005). "Safranal, a constituent of Crocus sativus (saffron), attenuated cerebral ischemia induced oxidative damage in rat hippocampus". J Pharm Pharm Sci. 8 (3). ss. 394-9. PMID 16401389.
Assimopoulou AN, Sinakos Z, Papageorgiou VP. (2005). "Radical scavenging activity of Crocus sativus L. extract and its bioactive constituents". Phytother Res. 19 (11). ss. 997-1000. PMID 16317646.
Escribano J, Alonso GL, Coca-Prados M, Fernandez JA. (1996). "Crocin, safranal and picrocrocin from saffron (Crocus sativus L.) inhibit the growth of human cancer cells in vitro". Cancer Lett. Cilt 100. ss. 23-30. PMID 8620447.

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[anticonvulsant-Hosseinzadeh-1] Hosseinzadeh H, Talebzadeh F. (2005). "Anticonvulsant evaluation of safranal and crocin from Crocus sativus in mice". Fitoterapia. 76 (7–8). ss. 722-4. PMID 16253437.

[protective-effect-Hosseinzadeh-2] Hosseinzadeh H, Sadeghnia HR. (2006). "Protective effect of safranal on pentylenetetrazol-induced seizures in the rat: Involvement of GABAergic and opioids systems". Phytomedicine. ? (?). ss. ?. PMID 16707256.

[Safranal-a-constituent-Hosseinzadeh-3] Hosseinzadeh H, Sadeghnia HR. (2005). "Safranal, a constituent of Crocus sativus (saffron), attenuated cerebral ischemia induced oxidative damage in rat hippocampus". J Pharm Pharm Sci. 8 (3). ss. 394-9. PMID 16401389.

[Radical-scavenging-Assimopoulou-4] Assimopoulou AN, Sinakos Z, Papageorgiou VP. (2005). "Radical scavenging activity of Crocus sativus L. extract and its bioactive constituents". Phytother Res. 19 (11). ss. 997-1000. PMID 16317646.

[Crocin-safranal-Escribano-5] Escribano J, Alonso GL, Coca-Prados M, Fernandez JA. (1996). "Crocin, safranal and picrocrocin from saffron (Crocus sativus L.) inhibit the growth of human cancer cells in vitro". Cancer Lett. Cilt 100. ss. 23-30. PMID 8620447.